Ether hydrochloride → 3-(6-Nitro-3-pyridinyl)-3,8-diazabicyclo[3.2.1]octane dihydrochloride

반응식

[N+:1]([C:4]1[N:9]=[CH:8][C:7]([N:10]2[CH2:16][CH:15]3[N:17](C(OC(C)(C)C)=O)[CH:12]([CH2:13][CH2:14]3)[CH2:11]2)=[CH:6][CH:5]=1)([O-:3])=[O:2].[ClH:25].CCOCC>>[ClH:25].[ClH:25].[N+:1]([C:4]1[N:9]=[CH:8][C:7]([N:10]2[CH2:16][CH:15]3[NH:17][CH:12]([CH2:13][CH2:14]3)[CH2:11]2)=[CH:6][CH:5]=1)([O-:3])=[O:2]

참가 물질

반응물 2

HCID 10953452Ether hydrochloride

HCID 67356030Tert-butyl 3-(6-nitro-3-pyridinyl)-3,8-diazabicyclo[3.2.1]octane-8-carboxylate

생성물 1

HCID 692884503-(6-Nitro-3-pyridinyl)-3,8-diazabicyclo[3.2.1]octane dihydrochloride수율 55%

실험 절차

The product from Example 10A was treated with 1M HCl/ether to provide the title compound (55% yield). 1H NMR (DMSO-d6, 300 MHz) δ 1.9-2.0 (m, 4H), 3.4-3.5 (m, 2H), 4.00 (d, J=11 Hz, 2H), 4.20 (br s, 2H), 7.5-7.6 (m, 1H), 8.2-8.3 (m, 2H), 9.6-9.7 (br s, 3H, exchangeable).

출처 및 근거

ORD 기록: ord-37064ebb20c3424a88d2b1f93ddbfa6c
출처 데이터셋: uspto-grants-2007_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07265115B2

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