Ethyl Acetate → HCID 87214300, 화합물

HRID 914790노트

반응식

HRID 914790 반응식
[F:1][C:2]1[C:10]([O:11][C:12]2[C:17]3=[C:18]([CH3:25])[C:19](C(O)(C)C)=[CH:20][N:16]3[N:15]=[CH:14][N:13]=2)=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([CH3:26])[NH:6]2.[C:27]([O-:30])([O-])=O.[K+].[K+].[C:33](OCC)(=[O:35])[CH3:34]>CN(C=O)C>[F:1][C:2]1[C:10]([O:11][C:12]2[C:17]3=[C:18]([CH3:25])[C:19]([O:35][CH2:33][C@@H:34]4[CH2:27][O:30]4)=[CH:20][N:16]3[N:15]=[CH:14][N:13]=2)=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([CH3:26])[NH:6]2

참가 물질

5

반응물 3

HCID 8857Ethyl AcetateHCID 11430Potassium CarbonateHCID 223379962-{4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl}propan-2-ol

생성물 1

HCID 87214300HCID 87214300, 화합물수율 92%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A mixture of Example 1 (311 mg, 1 mmol), (2S)-(+)-glycidyl nosylate (311 mg, 1.2 mmol), and K2CO3 (200 mg, 1.45 mmol) in DMF (3 mL) was stirred at RT for 4 hr. The mixture was diluted with ethyl acetate and the solids were filtered. The filtrate was washed with brine, dried, and concentrated. The residue was purified by flash column chromatography (silica gel, 50% ethyl acetate in hexanes) to afford the title compound (340 mg, 92% yield). LC/MS; (M+H)+=369.1

후처리

  1. filtrationthe solids were filtered
  2. washThe filtrate was washed with brine
  3. customdried
  4. concentrationconcentrated
  5. customThe residue was purified by flash column chromatography (silica gel, 50% ethyl acetate in hexanes)

출처 및 근거

ORD 기록
ord-c8dedf8352aa4c2f91991e45493b68b3
출처 데이터셋
uspto-grants-2007_09
특허 번호
US07265113B2

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