Hydrogen chloride-ethyl acetate → 4-Hydroxy-4-[(2-fluorophenyl)ethynyl]piperidine hydrochloride

HRID 914897노트

반응식

HRID 914897 반응식
C(OC([N:8]1[CH2:13][CH2:12][C:11]([OH:23])([C:14]#[C:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[F:22])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:24].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:24].[OH:23][C:11]1([C:14]#[C:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[F:22])[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

참가 물질

4

반응물 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 222482031-(Tert-butoxycarbonyl)-4-hydroxy-4-[(2-fluorophenyl)ethynyl]piperidine

생성물 1

HCID 222484404-Hydroxy-4-[(2-fluorophenyl)ethynyl]piperidine hydrochloride

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

After dissolving 1.4 g of 1-(tert-butoxycarbonyl)-4-hydroxy-4-[(2-fluorophenyl)ethynyl]piperidine in 20 ml of ethyl acetate, 10 ml of 4N hydrogen chloride/ethyl acetate was added and the mixture was stirred overnight at room temperature. The solvent was distilled off under reduced pressure to obtain 1.28 g of 4-hydroxy-4-[(2-fluorophenyl)ethynyl]piperidine hydrochloride.

후처리

  1. additionwas added
  2. distillationThe solvent was distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-98590ceb2b2e4b0fa7294d8f3dd1d1a4
출처 데이터셋
uspto-grants-2007_09
특허 번호
US07265108B2

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