Methanesulfonyl chloride → 2-(3-Nitro-benzenesulfonyl)ethyl methanesulfonate

HRID 914995노트

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HRID 914995 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([S:10]([CH2:13][CH2:14][OH:15])(=[O:12])=[O:11])[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].[CH3:16][S:17](Cl)(=[O:19])=[O:18]>ClCCl.N1C=CC=CC=1>[CH3:16][S:17]([O:15][CH2:14][CH2:13][S:10]([C:6]1[CH:7]=[CH:8][CH:9]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=1)(=[O:12])=[O:11])(=[O:19])=[O:18]

참가 물질

5

반응물 2

HCID 31297Methanesulfonyl chlorideHCID 170561Ethanol, 2-[(3-nitrophenyl)sulfonyl]-

생성물 1

HCID 589580692-(3-Nitro-benzenesulfonyl)ethyl methanesulfonate수율 71.5%

시약·촉매·용매 2

HCID 1049Pyridine용매HCID 6344Dichloromethane용매

실험 절차

To a solution of 2-(3-nitrobenzenesulfonyl)ethanol (101) (5.0 g, 21.6 mmol) in dichloromethane (31.5 mL) and pyridine (7 mL) was added methanesulfonyl chloride (4.9 g, 43 mmol). The mixture was stirred at room temperature overnight before it was partitioned between dichloromethane (200 mL) and 0.5 N HCl (200 mL). The organic layer was dried over MgSO4 and concentrated on a rotavap to give 102 (4.78 g, 71%).

후처리

  1. customwas partitioned between dichloromethane (200 mL) and 0.5 N HCl (200 mL)
  2. dry with materialThe organic layer was dried over MgSO4
  3. concentrationconcentrated on a rotavap

출처 및 근거

ORD 기록
ord-08464b2f7870468fa69c150e600cc333
출처 데이터셋
uspto-grants-2007_09
특허 번호
US07265122B2

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