2-(1,2,3,4-Tetrahydroisoquinolin-2-yl)ethan-1-amine → N-[2-(4-Benzylpiperidin-1-yl)ethyl]-N'-(2-methylquinolin-4-yl)pyrimidine-4,6-diamine

참여 물질

역할	이름	HCID	투입량
반응물	2-(1,2,3,4-Tetrahydroisoquinolin-2-yl)ethan-1-amine	HCID 40742	—
반응물	Diisopropylethylamine	HCID 81531	—
반응물	(6-Chloropyrimidin-4-yl)-(2-methylquinolin-4-yl)amine	HCID 58958180	—
용매	1-Butanol	HCID 263	—
생성물	N-[2-(4-Benzylpiperidin-1-yl)ethyl]-N'-(2-methylquinolin-4-yl)pyrimidine-4,6-diamine	HCID 10479037	25%

반응 조건

온도	100 °C

반응 단계

To a solution of diamine 36 (0.05 g, 0.21 mmol) in n-BuOH (2 mL) were sequentially added 108 (0.05 g, 0.18 mmol) and diisopropylethylamine (37 mg, 0.27 mmol). The mixture was heated at 100° C. overnight before the volatiles were removed under reduced pressure. The residue was purified by flash chromatography (SiO2, gradient elution, 3:1 hexanes/ethyl acetate to 7:3 CH2Cl2/MeOH) to yield the desired product (20 mg, 25%) as a yellow oil.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07265122B2
출처 데이터셋	uspto-grants-2007_09
ORD ID	ord-e7d619599b294df088693f06ba5b1e7f
출처 메모	uspto-grants-2007_09