Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 9151생성일: 2026년 10월 24일
Thionicotinamide → N-Ethyl-N'-[7-(3-pyridyl)-4,5-dihydro[1,3]thiazolo[4',5': 3,4]benzo[d][1,3]thiazol-2-yl]urea
https://huagongshe.com/ko/reaction/9151
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Thionicotinamide | HCID 737155 | — |
| 반응물 | 1-(6-Bromo-7-oxo-4,5,6,7-tetrahydro-2-benzothiazolyl)-3-ethyl-urea | HCID 21985543 | — |
| 용매 | 1-Propanol | HCID 1031 | — |
| 생성물 | N-Ethyl-N'-[7-(3-pyridyl)-4,5-dihydro[1,3]thiazolo[4',5': 3,4]benzo[d][1,3]thiazol-2-yl]urea | HCID 86588975 | 36% |
반응 단계
A suspension of N-(6-bromo-7-oxo-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)-N′-ethylurea (25 mg, 0.079 mmol) and thionicotinamide (11 mg, 0.079 mmol) in n-propanol (0.4 mL) was heated to about 105° C. for about 16 hrs. The reaction mixture was concentrated in vacuo and the residual crude material was purified by preparative HPLC. 10 mg (36%) pure product was isolated.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07091227B2 |
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| 출처 데이터셋 | uspto-grants-2006_08 |
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| ORD ID | ord-a17813f0e3914b2492892bf738b5e7ad |
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| 출처 메모 | uspto-grants-2006_08 |
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