HCID 11486167, 화합물 → HCID 11191362, 화합물

HRID 915344노트

반응식

HRID 915344 반응식
[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][C:13]([N:17]3[CH:21]=[CH:20][CH:19]=[CH:18]3)=[CH:14][CH:15]=2)[C:10]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[C:9]1[C:28](O)=[O:29])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.C([O:34][C:35](=[O:42])[C@H:36]([CH2:38][CH:39]([CH3:41])[CH3:40])[NH2:37])C>O>[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][C:13]([N:17]3[CH:18]=[CH:19][CH:20]=[CH:21]3)=[CH:14][CH:15]=2)[C:10]([C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)=[C:9]1[C:28]([NH:37][C@H:36]([C:35]([OH:34])=[O:42])[CH2:38][CH:39]([CH3:40])[CH3:41])=[O:29])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 11486167HCID 11486167, 화합물HCID 11658447L-Leucine, ethyl ester, hydrochloride (1:1)

생성물 1

HCID 11191362HCID 11191362, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

The title compound was prepared from 1-benzyl-3-phenyl-5-(1H-pyrrol-1-yl)-1H-indole-2-carboxylic acid and L-leucine ethyl ester hydrochloride followed the procedure of Example 2 Step 4 as a white solid: 1H NMR (DMSO-d6) δ 0.76 (d, J=6.5 Hz, 3 H), 0.77 (d, J=6.5 Hz, 3 H), 1.20-1.40 (m, 1 H), 1.40-1.50 (m, 1 H), 1.50-1.60 (m, 1H), 4.28-4.40 (m, 1 H), 5.55 (d, J=16.1 Hz, 1 H), 5.61 (d, J=16.2 Hz, 1 H), 6.21 (t, J=2.0 Hz, 2 H), 7.20-7.50 (m, 12 H), 7.55-7.65 (m, 3 H), 8.89 (d, J=7.8 Hz, 1 H), 12.64 (br s, 1 H); MS (ESI) m/z 506 (MH+); MS (ESI) m/z 504 ([M-H]−); HRMS calcd for C32H32N3O3: 506.2444; found (ESI+): 506.2429; Anal. calcd for C32H31N3O3.0.25 H2O: C, 75.35; H, 6.22; N, 8.23. Found: C, 75.42; H, 5.86; N, 7.98.

출처 및 근거

ORD 기록
ord-432801af3d3247f68c367a151d6df684
출처 데이터셋
uspto-grants-2007_09
특허 번호
US07265148B2

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