2,3-Dichloro-5,6-dicyano-1,4-benzoquinone → N-[7-(4-Bromoanilino) [1,3]thiazolo [4',5':3,4]benzo[d][1,3]thiazol-2-yl]-N'-ethylurea

참여 물질

역할	이름	HCID	투입량
반응물	2,3-Dichloro-5,6-dicyano-1,4-benzoquinone	HCID 6775	—
반응물	N-[7-(4-Bromoanilino)-4,5-dihydro[1,3]thiazolo[4',5': 3,4]benzo[d][1,3]thiazol-2-yl]-N'-ethylurea	HCID 86588976	—
용매	Toluene	HCID 1140	—
생성물	N-[7-(4-Bromoanilino) [1,3]thiazolo [4',5':3,4]benzo[d][1,3]thiazol-2-yl]-N'-ethylurea	HCID 86588977	—

반응 조건

온도	20 °C

반응 단계

To a suspension of N-[7-(4-bromoanilino)-4,5-dihydro[1,3]thiazolo[4′,5′: 3,4]benzo[d][1,3]thiazol-2-yl]-N′-ethylurea (27 mg, 0.060 mmol) in toluene (2.0 mL) was added DDQ (28 mg, 0.125 mmol). The reaction mixture was stirred at about 20° C. for about 2 hrs. The reaction mixture was pumped down in vacuo and purified by preparative HPLC. 7 mg (26%, 2 steps) pure product was isolated. LC/MS 448 and 450 (MH+); RP-HPLC 18.09 min.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07091227B2
출처 데이터셋	uspto-grants-2006_08
ORD ID	ord-108f08c279ff47c1a94c99a2e3501eb7
출처 메모	uspto-grants-2006_08