Tetrabutylammonium Fluoride → [4-bromo-2-methyl-5-(4-trifluoromethyl-phenyl)-2H-pyrazol-3-yl]-methanol

HRID 915414노트

반응식

HRID 915414 반응식
[Br:1][C:2]1[C:3]([C:17]2[CH:22]=[CH:21][C:20]([C:23]([F:26])([F:25])[F:24])=[CH:19][CH:18]=2)=[N:4][N:5]([CH3:16])[C:6]=1[C:7](C)(C)[O:8][SiH2]C(C)(C)C.[F-].C([N+](CCCC)(CCCC)CCCC)CCC>C1COCC1>[Br:1][C:2]1[C:3]([C:17]2[CH:22]=[CH:21][C:20]([C:23]([F:24])([F:26])[F:25])=[CH:19][CH:18]=2)=[N:4][N:5]([CH3:16])[C:6]=1[CH2:7][OH:8]

참가 물질

4

반응물 2

HCID 2724141Tetrabutylammonium FluorideHCID 1317265814-bromo-5-(tert-butyl-dimethyl-silanyloxymethyl)-1-methyl-3-(4-trifluoromethyl-phenyl)-1H-pyrazole

생성물 1

HCID 69284507[4-bromo-2-methyl-5-(4-trifluoromethyl-phenyl)-2H-pyrazol-3-yl]-methanol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

In analogy to the procedure described for example 2 e], 4-bromo-5-(tert-butyl-dimethyl-silanyloxymethyl)-1-methyl-3-(4-trifluoromethyl-phenyl)-1H-pyrazole was treated with tetrabutylammonium fluoride in THF to yield [4-bromo-2-methyl-5-(4-trifluoromethyl-phenyl)-2H-pyrazol-3-yl]-methanol as yellow oil.

출처 및 근거

ORD 기록
ord-fa6425cc2f0b41c286ba8255ee1fcd36
출처 데이터셋
uspto-grants-2007_09
특허 번호
US07265149B2

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