Aluminium lithium hydride → {1-methyl-3-[4-(trifluoromethoxy)phenyl]-1H-pyrazol-5-yl}methanol

HRID 915430

반응식

HRID 915430 반응식
C([O:3][C:4]([C:6]1[N:7]([CH3:22])[N:8]=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([O:17][C:18]([F:21])([F:20])[F:19])=[CH:13][CH:12]=2)[CH:10]=1)=O)C.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[CH3:22][N:7]1[C:6]([CH2:4][OH:3])=[CH:10][C:9]([C:11]2[CH:12]=[CH:13][C:14]([O:17][C:18]([F:19])([F:20])[F:21])=[CH:15][CH:16]=2)=[N:8]1

참가 물질

3

반응물 2

HCID 21226445Aluminium lithium hydrideHCID 67402503HCID 67402503, 화합물

생성물 1

HCID 44818672{1-methyl-3-[4-(trifluoromethoxy)phenyl]-1H-pyrazol-5-yl}methanol

실험 절차

In analogy to the procedure described for example 1 a], 2-methyl-5-(4-trifluoromethoxy-phenyl)-2H-pyrazole-3-carboxylic acid ethyl ester was reduced with lithium aluminium hydride to give [2-methyl-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-yl]-methanol as white crystals.

출처 및 근거

ORD 기록
ord-5c87e04c25ac479f9dc500bf6afc84d6
출처 데이터셋
uspto-grants-2007_09
특허 번호
US07265149B2

연결된 노트

불러오는 중…