Acetonitrile → [2-methyl-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-yl]-acetonitrile

HRID 915465노트

반응식

HRID 915465 반응식
Cl[CH2:2][C:3]1[N:7]([CH3:8])[N:6]=[C:5]([C:9]2[CH:14]=[CH:13][C:12]([O:15][C:16]([F:19])([F:18])[F:17])=[CH:11][CH:10]=2)[CH:4]=1.[C:20](#[N:22])C>[C-]#N.C([N+](CCCC)(CCCC)CCCC)CCC>[CH3:8][N:7]1[C:3]([CH2:2][C:20]#[N:22])=[CH:4][C:5]([C:9]2[CH:14]=[CH:13][C:12]([O:15][C:16]([F:19])([F:18])[F:17])=[CH:11][CH:10]=2)=[N:6]1

참가 물질

4

반응물 2

HCID 6342AcetonitrileHCID 674021555-chloromethyl-1-methyl-3-(4-trifluoromethoxy-phenyl)-1H-pyrazole

생성물 1

HCID 67402912[2-methyl-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-yl]-acetonitrile

시약·촉매·용매 1

HCID 165872Tetrabutylammonium Cyanide촉매

실험 절차

In analogy to the procedure described for example 9 b], 5-chloromethyl-1-methyl-3-(4-trifluoromethoxy-phenyl)-1H-pyrazole was reacted with tetrabutylammonium cyanide in acetonitrile to give [2-methyl-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-yl]-acetonitrile as yellow solid.

출처 및 근거

ORD 기록
ord-db908bba686f4c97bc9a80a0f08ec2b8
출처 데이터셋
uspto-grants-2007_09
특허 번호
US07265149B2

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