N,N,N',N'-Tetramethylazodicarboxamide → [Rac]-2-{6-[2-(2,2,2-trifluoro-ethyl)-5-(4-trifluoromethoxy-phenyl)-2h-pyrazol-3-ylmethoxy]-indol-1-yl}-propionic acid ethyl ester

참여 물질

역할	이름	HCID	투입량
반응물	N,N,N',N'-Tetramethylazodicarboxamide	HCID 4278	—
반응물	Tributylphosphine	HCID 13831	—
반응물	[Rac]-2-(6-hydroxy-indol-1-yl)-propionic acid ethyl ester	HCID 68826438	—
반응물	[2-(2,2,2-trifluoro-ethyl)-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-yl]-methanol	HCID 86600629	—
생성물	[Rac]-2-{6-[2-(2,2,2-trifluoro-ethyl)-5-(4-trifluoromethoxy-phenyl)-2h-pyrazol-3-ylmethoxy]-indol-1-yl}-propionic acid ethyl ester	HCID 87766039	—

반응 단계

In analogy to the procedure described for example 3 c], [rac]-2-(6-hydroxy-indol-1-yl)-propionic acid ethyl ester (J. E. D. Barton, D. Cartwright, C. J. Mathews, Brit. UK Pat. Appl. (1992), GB 2253848 A1) was reacted with [2-(2,2,2-trifluoro-ethyl)-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-yl]-methanol (example 15 b]) in the presence of N,N,N′,N′-tetramethyl azodicarboxamide and tributylphosphine to give [rac]-2-{6-[2-(2,2,2-trifluoro-ethyl)-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-ylmethoxy]-indol-1-yl}-propionic acid ethyl ester as colorless oil.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07265149B2
출처 데이터셋	uspto-grants-2007_09
ORD ID	ord-230b193bda9f441e977a1b73d3156c68
출처 메모	uspto-grants-2007_09