Sodium Iodide → 5-iodomethyl-1-methyl-3-(4-trifluoromethyl-phenyl)-1H-pyrazole

HRID 915488노트

반응식

HRID 915488 반응식
Cl[CH2:2][C:3]1[N:7]([CH3:8])[N:6]=[C:5]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)[CH:4]=1.[I-:19].[Na+]>CC(C)=O>[I:19][CH2:2][C:3]1[N:7]([CH3:8])[N:6]=[C:5]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)[CH:4]=1

참가 물질

4

반응물 2

HCID 5238Sodium IodideHCID 210822245-chloromethyl-1-methyl-3-(4-trifluoromethyl-phenyl)-1H-pyrazole

생성물 1

HCID 692828125-iodomethyl-1-methyl-3-(4-trifluoromethyl-phenyl)-1H-pyrazole

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

In analogy to the procedure described in example 20 a], 5-chloromethyl-1-methyl-3-(4-trifluoromethyl-phenyl)-1H-pyrazole (example 9 a]) was treated with sodium iodide in acetone to obtain 5-iodomethyl-1-methyl-3-(4-trifluoromethyl-phenyl)-1H-pyrazole as yellow solid which was used in the next step without further purification.

출처 및 근거

ORD 기록
ord-6bf43f8f2469435dbe68adff14dfc595
출처 데이터셋
uspto-grants-2007_09
특허 번호
US07265149B2

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