Triethylamine → N-benzoyl-N'-[3-[4-(3,4-dichlorophenoxy)-1-piperidinyl]propyl]-sulfamide

HRID 915545노트

반응식

HRID 915545 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:15]=[CH:16][C:17]=1[Cl:18])[O:5][CH:6]1[CH2:11][CH2:10][N:9]([CH2:12][CH2:13]N)[CH2:8][CH2:7]1.[CH2:19]([N:21](CC)CC)C.[C:26]([NH:34][S:35](Cl)(=[O:37])=[O:36])(=[O:33])[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>ClCCl>[C:26]([NH:34][S:35]([NH:21][CH2:19][CH2:13][CH2:12][N:9]1[CH2:8][CH2:7][CH:6]([O:5][C:4]2[CH:15]=[CH:16][C:17]([Cl:18])=[C:2]([Cl:1])[CH:3]=2)[CH2:11][CH2:10]1)(=[O:37])=[O:36])(=[O:33])[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 113582094-(3,4-Dichlorophenoxy)-1-piperidineethanamineHCID 11830956Benzoylsulfamoyl chloride

생성물 1

HCID 69420940N-benzoyl-N'-[3-[4-(3,4-dichlorophenoxy)-1-piperidinyl]propyl]-sulfamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

4-(3,4-Dichlorophenoxy)-1-piperidineethanamine (0.16 g) was dissolved in dichloromethane (2 ml) and triethylamine (88 μl) was added. Benzoylsulfamoyl chloride (0.13 g) was added and the solution was stirred for 16 h. The solvent was evaporated and the residue was purified by HPLC (ammonium acetate: acetonitrile 95% to 5% aq) to give the title compound (6 mg).

후처리

  1. customThe solvent was evaporated
  2. customthe residue was purified by HPLC (ammonium acetate: acetonitrile 95% to 5% aq)

출처 및 근거

ORD 기록
ord-ecc7985fd6f64511802911b351fe8c2a
출처 데이터셋
uspto-grants-2007_09
특허 번호
US07265227B2

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