3-tert-Butyl-1-(2-methylphenyl)-1H-pyrazol-5-amine → methyl 2-{[3-tert-butyl-1-(2-methylphenyl)-1H-pyrazol-5-yl]amino}-4-chlorobenzoate

HRID 915588

반응식

HRID 915588 반응식
[C:1]([C:5]1[CH:9]=[C:8]([NH2:10])[N:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[CH3:17])[N:6]=1)([CH3:4])([CH3:3])[CH3:2].Br[C:19]1[CH:28]=[C:27]([Cl:29])[CH:26]=[CH:25][C:20]=1[C:21]([O:23][CH3:24])=[O:22]>>[C:1]([C:5]1[CH:9]=[C:8]([NH:10][C:19]2[CH:28]=[C:27]([Cl:29])[CH:26]=[CH:25][C:20]=2[C:21]([O:23][CH3:24])=[O:22])[N:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[CH3:17])[N:6]=1)([CH3:4])([CH3:3])[CH3:2]

참가 물질

3

반응물 2

HCID 7706433-tert-Butyl-1-(2-methylphenyl)-1H-pyrazol-5-amineHCID 15110995Methyl 2-Bromo-4-chlorobenzoate

생성물 1

HCID 58958608methyl 2-{[3-tert-butyl-1-(2-methylphenyl)-1H-pyrazol-5-yl]amino}-4-chlorobenzoate

실험 절차

This compound was prepared using the procedure described in Example 234 and Intermediate C and methyl 2-bromo-4-chlorobenzoate as starting materials. 1H NMR (300 MHz, CD2Cl2) δ 9.33 (s, 1H), 7.84 (d, 1H), 7.20-7.30 (m, 4H), 7.15 (s, 1H), 6.68 (d, 1H), 6.13 (s, 1H), 3.72 (s, 3H), 2.06 (s, 3H), 1.31 (s, 9H). ES-MS m/z 398.3 (MH)+; HPLC RT (min) 4.27.

후처리

  1. customThis compound was prepared

출처 및 근거

ORD 기록
ord-da20194ddedd462a8de5b348bfc55f38
출처 데이터셋
uspto-grants-2007_09
특허 번호
US07265144B2

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