Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sulfuric Acid → 2-(4-Bromo-3-oxobutyl)-1H-isoindole-1,3(2H)-dione
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sulfuric Acid | HCID 1118 | — |
| 반응물 | Bromine | HCID 24408 | — |
| 반응물 | 2-(3-Oxobutyl)isoindoline-1,3-dione | HCID 290728 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 2-(4-Bromo-3-oxobutyl)-1H-isoindole-1,3(2H)-dione | HCID 3759744 | 24.7% |
반응 단계
Prepare a cold (0° C.) solution of 2-(3-oxobutyl)isoindole-1,3-dione (6.8 g, 31.5 mmol) in methanol (50 mL). Add Br2 (3.2 mL, 63 mmol). Allow the reaction to warm to room temperature and stir for 15 hours. Add 10 M sulfuric acid (26 mL) and stir the mixture for 15 hours. Filter off the solids and dry in vacuo to afford 2-(4-bromo-3-oxobutyl)isoindole-1,3-dione (2.3 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07265246B2 |
| 출처 데이터셋 | uspto-grants-2007_09 |
| ORD ID | ord-736dea6486824a4bb56436fa6faa2d2e |
| 출처 메모 | uspto-grants-2007_09 |