2,3-Dichloro-5,6-dicyano-1,4-benzoquinone → N-Ethyl-N'-(8H-[1,3]thiazolo[4,5-g]indol-2-yl)urea

참여 물질

역할	이름	HCID	투입량
반응물	2,3-Dichloro-5,6-dicyano-1,4-benzoquinone	HCID 6775	—
반응물	N-(5,8-dihydro-4H-[1,3]thiazolo[4,5-g]indol-2-yl)-N'-ethylurea	HCID 21985605	—
용매	Toluene	HCID 1140	—
생성물	N-Ethyl-N'-(8H-[1,3]thiazolo[4,5-g]indol-2-yl)urea	HCID 21985599	—

반응 조건

온도	45 °C

반응 단계

To a suspension of N-(5,8-dihydro-4H-[1,3]thiazolo[4,5-g]indol-2-yl)-N′-ethylurea (81 mg, 0.308 mmol) in toluene (3.5 mL) was added DDQ (78 mg, 0.34 mmol). The reaction mixture was stirred at about 45° C. for about 4 hrs. The reaction mixture was pumped down and the crude material was purified by preparative HPLC. 3 mg (4%, 2 steps) pure product was isolated. LC/MS 262 (MH+); RP-BPLC RT 10.45 min.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07091227B2
출처 데이터셋	uspto-grants-2006_08
ORD ID	ord-5a0dc76b8b9c408797b9d2afd2580814
출처 메모	uspto-grants-2006_08