Pyridine → 5-Chloro-2-(2,2-difluoroacetamido)benzenesulphonamide

HRID 915743

반응식

HRID 915743 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[S:9]([NH2:12])(=[O:11])=[O:10].N1C=CC=CC=1.[F:19][CH:20]([F:24])[C:21](Cl)=[O:22]>O1CCOCC1>[Cl:8][C:5]1[CH:6]=[CH:7][C:2]([NH:1][C:21](=[O:22])[CH:20]([F:24])[F:19])=[C:3]([S:9]([NH2:12])(=[O:11])=[O:10])[CH:4]=1

참가 물질

5

반응물 3

HCID 1049PyridineHCID 27368902,2-Difluoroacetyl chlorideHCID 122955502-Amino-5-chlorobenzenesulphonamide

생성물 1

HCID 231042325-Chloro-2-(2,2-difluoroacetamido)benzenesulphonamide

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

To 1 g of 2-amino-5-chlorobenzenesulphonamide (obtained in accordance with J. Chem. Soc. Perkin I 1979, 1043-1047) dissolved in 4 ml of dioxane there are added, in the cold state (+5° C.), 0.6 ml of pyridine and 0.6 ml of difluoroacetic acid chloride. The flask is hermetically closed immediately and subjected to vigorous stirring at ambient temperature for 10 minutes. The solvents are then removed under reduced pressure. The solid residue is taken up in water (12 ml), and the insoluble material is collected by filtration, washed with water and dried to yield the expected compound.

후처리

  1. customThe flask is hermetically closed immediately
  2. customThe solvents are then removed under reduced pressure
  3. filtrationthe insoluble material is collected by filtration
  4. washwashed with water
  5. customdried

출처 및 근거

ORD 기록
ord-9d2c3e9d62a24924ad2245c0bdc30ea4
출처 데이터셋
uspto-grants-2007_09
특허 번호
US07268129B2

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