Benzyl methyl(piperidin-4-yl)carbamate hydrochloride → Benzyl 1-[4-(3-cyclohexyl-1-methyl-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-3-ethoxyphenyl]-4-piperidinyl(methyl)carbamate

HRID 915942노트

반응식

HRID 915942 반응식
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:9][C:10](=[O:24])[C:11]3[C:16]([CH:17]4[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]4)=[N:15][N:14]([CH3:23])[C:12]=3[N:13]=2)=[C:4]([O:25][CH2:26][CH3:27])[CH:3]=1.Cl.[CH3:29][N:30]([CH:41]1[CH2:46][CH2:45][NH:44][CH2:43][CH2:42]1)[C:31](=[O:40])[O:32][CH2:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1>>[CH:17]1([C:16]2[C:11]3[C:10](=[O:24])[NH:9][C:8]([C:5]4[CH:6]=[CH:7][C:2]([N:44]5[CH2:43][CH2:42][CH:41]([N:30]([CH3:29])[C:31](=[O:40])[O:32][CH2:33][C:34]6[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=6)[CH2:46][CH2:45]5)=[CH:3][C:4]=4[O:25][CH2:26][CH3:27])=[N:13][C:12]=3[N:14]([CH3:23])[N:15]=2)[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1

참가 물질

3

반응물 2

HCID 18677745Benzyl methyl(piperidin-4-yl)carbamate hydrochlorideHCID 136005963HCID 136005963, 화합물

생성물 1

HCID 136333210Benzyl 1-[4-(3-cyclohexyl-1-methyl-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-3-ethoxyphenyl]-4-piperidinyl(methyl)carbamate수율 77%

실험 절차

The same reaction procedure as in Example 27 was performed, except that the compound obtained in Example 85 was used in place of the compound obtained in Example 26, and benzyl methyl(4-piperidinyl)carbamate hydrochloride was used in place of N-methylpiperazine. In this manner, 234 mg (77%) of the captioned compound was obtained.

후처리

  1. customThe same reaction procedure as in Example 27

출처 및 근거

ORD 기록
ord-0bfbadf1fe8b467f8152c5da47e8a2a7
출처 데이터셋
uspto-grants-2007_09
특허 번호
US07268128B2

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