참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Piperazine | HCID 4837 | — |
| 반응물 | N-(6-bromo-1,3-benzothiazol-2-yl)-N'-(3-chloropropyl)urea | HCID 21985572 | — |
| 용매 | Tetrahydrofuran ethanol | HCID 21873804 | — |
| 생성물 | N-(6-Bromo-1,3-benzothiazol-2-yl)-N'-(3-piperazinopropyl)urea | HCID 21985562 | — |
반응 단계
To a mixture of N-(6-bromo-1,3-benzothiazol-2-yl)-N′-(3-chloropropyl)urea (100 mg, 0.287 mmol) in THF/EtOH (0.50/0.25 mL) was added piperazine (247 mg, 2.87 mmol). The reaction mixture was heated to about 55° C. for about 16 hrs. The crude reaction mixture was pumped down and purified by flash chromatography on SiO2.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07091227B2 |
|---|
| 출처 데이터셋 | uspto-grants-2006_08 |
|---|
| ORD ID | ord-8cc7371e38f3460581b5e22886eb5510 |
|---|
| 출처 메모 | uspto-grants-2006_08 |
|---|
