Hydrochloric Acid → 4-([(6-Bromo-1,3-benzothiazol-2-yl)amino]carbonylamino)butanoic acid

참여 물질

역할	이름	HCID	투입량
반응물	Hydrochloric Acid	HCID 313	—
반응물	Sodium Hydroxide	HCID 14798	—
반응물	Ethyl 4-([(6-bromo-1,3-benzothiazol-2-yl)amino]carbonylamino)butanoate	HCID 21985597	—
용매	Tetrahydrofuran ethanol	HCID 21873804	—
생성물	4-([(6-Bromo-1,3-benzothiazol-2-yl)amino]carbonylamino)butanoic acid	HCID 21985624	15.4%

반응 조건

온도	20 °C

반응 단계

To a solution of ethyl 4-([(6-bromo-1,3-benzothiazol-2-yl)amino]carbonylamino)-butanoate (175 mg, 0.453 mmol) in THF/EtOH (1/1, 3 mL) was added 2 M NaOH (2.26 mL, 4.53 mmol). The reaction mixture was stirred at about 20° C. for about 3 hrs then 2 M HCl was added until pH<6 and a white precipitate was formed. The precipitate was filtered off and washed with H2O. 25 mg (15%) pure product was isolated.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07091227B2
출처 데이터셋	uspto-grants-2006_08
ORD ID	ord-eeb2af849bb244f29f28bc6c0698016c
출처 메모	uspto-grants-2006_08