Thiomorpholine → 4-Thiomorpholin-4-ylnaphthalene-1-carbonitrile

반응식

[C:1]([C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6](F)=[CH:5][CH:4]=1)#[N:2].[NH:14]1[CH2:19][CH2:18][S:17][CH2:16][CH2:15]1>>[N:14]1([C:6]2[C:7]3[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=3)[C:3]([C:1]#[N:2])=[CH:4][CH:5]=2)[CH2:19][CH2:18][S:17][CH2:16][CH2:15]1

참가 물질

반응물 2

HCID 67164Thiomorpholine

HCID 27367341-Cyano-4-fluoronaphthalene

생성물 1

HCID 116445524-Thiomorpholin-4-ylnaphthalene-1-carbonitrile수율 20.2%

실험 절차

The title compound (6 mg, 20% yield) was prepared as described for 196MBT2-4 from 1-cyano-4-fluoronaphthalene (20 mg, 0.117 mmol) and thiomorpholine (48 mg, 0.468 mmol).

출처 및 근거

ORD 기록: ord-c6bd397127314b55a92232ac8d9e4772
출처 데이터셋: uspto-grants-2007_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07268232B2

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