Phenyl(piperidin-4-yl)methanone → 4-(4-Benzoylpiperidin-1-yl)naphthalene-1-carbonitrile

반응식

[C:1]([C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6](F)=[CH:5][CH:4]=1)#[N:2].[C:14]([CH:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1)(=[O:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[C:14]([CH:22]1[CH2:27][CH2:26][N:25]([C:6]2[C:7]3[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=3)[C:3]([C:1]#[N:2])=[CH:4][CH:5]=2)[CH2:24][CH2:23]1)(=[O:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

참가 물질

반응물 2

HCID 226102Phenyl(piperidin-4-yl)methanone

HCID 27367341-Cyano-4-fluoronaphthalene

생성물 1

HCID 692260984-(4-Benzoylpiperidin-1-yl)naphthalene-1-carbonitrile수율 8%

실험 절차

The title compound (3 mg, 8% yield) was prepared as described for 196MBT2-4 from 1-cyano-4-fluoronaphthalene (20 mg, 0.117 mmol) and 4-benzoylpiperidine (89 mg, 0.468 mmol).

출처 및 근거

ORD 기록: ord-3c0b9d2cd4114abf8c04a3daba38762c
출처 데이터셋: uspto-grants-2007_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07268232B2

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