Water → 7-[2-(4-acetylpiperazin-1-yl)ethoxy]-4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxyquinazoline

참여 물질

역할	이름	HCID	투입량
반응물	Water	HCID 962	—
반응물	Potassium Carbonate	HCID 11430	—
반응물	1-Acetyl-4-(2-chloroethyl)piperazine	HCID 13289488	—
반응물	4-((4-Fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-ol	HCID 135530832	—
용매	N-methyl-2-pyrrolidone	HCID 13387	—
생성물	7-[2-(4-acetylpiperazin-1-yl)ethoxy]-4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxyquinazoline	HCID 11752254	84.9%

반응 조건

온도	90 °C

반응 단계

A mixture of 4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-7-hydroxy-6-methoxyquinazoline (250 mg, 0.74 mmol), 1-acetyl-4-(2-chloroethyl)piperazine (144 mg, 0.81 mmol) and potassium carbonate (112 mg, 0.81 mmol) in N-methylpyrrolidinone (6 ml) was heated at 90° C. for 2 hours. The mixture was cooled and water added. After 30 minutes the solid was filtered off and dried under vacuum. The residue was purified by column chromatography eluting with methylene chloride/methanol (saturated with ammonia) (96/4) to give 7-[2-(4-acetylpiperazin-1-yl)ethoxy]-4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxyquinazoline (310 mg, 58%) as a white solid.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07268230B2
출처 데이터셋	uspto-grants-2007_09
ORD ID	ord-257a0abbe41442cfad87136c87a3e653
출처 메모	uspto-grants-2007_09