참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 4-(4-Aminophenyl)butanoic acid | HCID 27049 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | Methyl 4-aminobenzenebutanoate | HCID 88628 | 91% |
반응 단계
To a solution of 4-(4-aminophenyl)-butyric acid (5 g, 27.90 mmol) in MeOH (100 mL) at room temperature was added HCl conc. (37% 15 mL). The resulting mixture was stirred overnight at 50° C. then treated with a saturated aqueous solution NaHCO3 and Na2CO3 solid until pH 9. The solvent was evaporated under reduced pressure then the aqueous phase was extracted several times with CH2Cl2. The crude material was purified by flash chromatography using CH2Cl2/MeOH as solvent mixture yielding 40 (4.93 g, 91%) as orange solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | USRE039850E1 |
|---|
| 출처 데이터셋 | uspto-grants-2007_09 |
|---|
| ORD ID | ord-c8e20f890da04c3e8d60e09bd7268c1d |
|---|
| 출처 메모 | uspto-grants-2007_09 |
|---|
