Acetic Acid → 4-Pyrimidinol, 6-methyl-5-propyl-

HRID 916635노트

반응식

HRID 916635 반응식
C[O-].[Na+].[CH:4]([NH2:6])=[NH:5].C[O:8][C:9](=O)[CH:10]([C:14](=O)[CH3:15])[CH2:11][CH2:12][CH3:13].C(O)(=O)C>CO>[CH2:11]([C:10]1[C:9](=[O:8])[NH:5][CH:4]=[N:6][C:14]=1[CH3:15])[CH2:12][CH3:13]

참가 물질

6

반응물 4

HCID 176Acetic AcidHCID 68047FormamidineHCID 10942334Sodium MethoxideHCID 14360044Methyl 2-acetylpentanoate

생성물 1

HCID 1355027734-Pyrimidinol, 6-methyl-5-propyl-

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

NaOMe (1.30 g, 24 mmol) is added to a stirred solution of formamidine (12 mmol) in MeOH (75 ml) at room temperature. The mixture is stirred for 15 minutes. 2-Acetyl-pentanoic acid methyl ester (10 mmol) is added and the mixture is stirred at room temperature overnight. Acetic acid (0.72 g, 12 mmol) is added and the solvent is removed in vacuo. Water (30 ml) is added to the residue and it is extracted with 2-butanone (3×30 ml). The combined extracts are washed with brine (40 ml), dried (Na2SO4) and evaporated, to provide a yellow solid (100), which is used in the next step without further purification.

후처리

  1. stirringthe mixture is stirred at room temperature overnight
  2. customthe solvent is removed in vacuo
  3. additionWater (30 ml) is added to the residue and it
  4. extractionis extracted with 2-butanone (3×30 ml)
  5. washThe combined extracts are washed with brine (40 ml)
  6. dry with materialdried (Na2SO4)
  7. customevaporated

출처 및 근거

ORD 기록
ord-81e28272e9524300a4369e301ab93afd
출처 데이터셋
uspto-grants-2007_09
특허 번호
US07271170B2

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