6-Azido-4-[2-(6-fluoro-pyridin-2-yl)-imidazol-1-ylmethyl]-5-propyl-pyrimidine → 6-Amino-4-[2-(6-fluoro-pyridin-2-yl)-imidazol-1-ylmethyl]-5-propyl-pyrimidine

HRID 916639노트

반응식

HRID 916639 반응식
[N:1]([C:4]1[N:9]=[CH:8][N:7]=[C:6]([CH2:10][N:11]2[CH:15]=[CH:14][N:13]=[C:12]2[C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([F:22])[N:17]=2)[C:5]=1[CH2:23][CH2:24][CH3:25])=[N+]=[N-]>CO.[Pd]>[NH2:1][C:4]1[N:9]=[CH:8][N:7]=[C:6]([CH2:10][N:11]2[CH:15]=[CH:14][N:13]=[C:12]2[C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([F:22])[N:17]=2)[C:5]=1[CH2:23][CH2:24][CH3:25]

참가 물질

4

반응물 1

HCID 223131686-Azido-4-[2-(6-fluoro-pyridin-2-yl)-imidazol-1-ylmethyl]-5-propyl-pyrimidine

생성물 1

HCID 117230296-Amino-4-[2-(6-fluoro-pyridin-2-yl)-imidazol-1-ylmethyl]-5-propyl-pyrimidine

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

Pd/C (10%, 10 mg) is added to a solution of 104 (2 mmol) in MeOH (20 ml). The mixture is stirred under H2 at 30 psi for 4 hours. The catalyst is removed by filtration and the filtrate is evaporated in vacuo. The light resulting yellow solid (105) is used in the next step without further purification.

후처리

  1. customThe catalyst is removed by filtration
  2. customthe filtrate is evaporated in vacuo

출처 및 근거

ORD 기록
ord-fd5ed461658f4a5e994264ca3414b1ec
출처 데이터셋
uspto-grants-2007_09
특허 번호
US07271170B2

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