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Ethyl Acetate → Acetic Acid 2-{4-chloro-6-[2-(3-fluoro-pyridin-2-yl)-imidazol-1-ylmethyl]-pyrimidin-5-yl}-ethyl ester

HRID 916658
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HRID 916658 반응식
Br[CH2:2][C:3]1[C:8]([CH2:9][CH2:10][O:11][C:12](=[O:14])[CH3:13])=[C:7]([Cl:15])[N:6]=[CH:5][N:4]=1.[F:16][C:17]1[C:18]([C:23]2[NH:24][CH:25]=[CH:26][N:27]=2)=[N:19][CH:20]=[CH:21][CH:22]=1.C([O-])([O-])=O.[K+].[K+].CCOC(C)=O>CN(C=O)C.O>[Cl:15][C:7]1[C:8]([CH2:9][CH2:10][O:11][C:12](=[O:14])[CH3:13])=[C:3]([CH2:2][N:24]2[CH:25]=[CH:26][N:27]=[C:23]2[C:18]2[C:17]([F:16])=[CH:22][CH:21]=[CH:20][N:19]=2)[N:4]=[CH:5][N:6]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 4

HCID 8857Ethyl AcetateHCID 11430Potassium CarbonateHCID 223131643-Fluoro-2-(1H-imidazol-2-yl)pyridineHCID 57503307Acetic Acid 2-(4-bromomethyl-6-chloro-pyrimidin-5-yl)-ethyl ester

생성물 1

HCID 57503309Acetic Acid 2-{4-chloro-6-[2-(3-fluoro-pyridin-2-yl)-imidazol-1-ylmethyl]-pyrimidin-5-yl}-ethyl ester

시약·촉매·용매 2

HCID 962
Water
용매
HCID 6228Dimethylformamide용매

실험 절차

A mixture of 162 (8.4 mmol), 3-fluoro-2-(1H-imidazol-2-yl)-pyridine (described above) (1.38 g, 8.4 mmol) and K2CO3 (1.17 g, 8.4 mmol) in DMF (6 ml) is stirred at room temperature overnight. To the mixture are added EtOAc (20 ml) and water (10 ml). The organic layer is separated and the aqueous layer is extracted with EtOAc (3×10 ml). The combined extracts are washed with brine (10 ml), dried (Na2SO4) and solvent evaporated. PTLC separation of the residue (5% MeOH in CH2Cl2) gives the product (163) as a white solid.

후처리

  1. customThe organic layer is separated
  2. extractionthe aqueous layer is extracted with EtOAc (3×10 ml)
  3. washThe combined extracts are washed with brine (10 ml)
  4. dry with materialdried (Na2SO4) and solvent
  5. customevaporated
  6. customPTLC separation of the residue (5% MeOH in CH2Cl2)

출처 및 근거

ORD 기록
ord-3ae0893890ae449489ee12669ddcd425
출처 데이터셋
uspto-grants-2007_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07271170B2

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