Sulfuric Acid → 1-Bromo-3-(dimethoxymethyl)benzene

HRID 916683노트

반응식

HRID 916683 반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]2[O:12][CH2:11][CH2:10][O:9]2)[CH:5]=[CH:6][CH:7]=1.OS(O)(=O)=O>CO>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH:8]([O:9][CH3:10])[O:12][CH3:11])[CH:3]=1

참가 물질

4

반응물 2

HCID 1118Sulfuric AcidHCID 873062-(3-Bromophenyl)-1,3-dioxolane

생성물 1

HCID 1053951-Bromo-3-(dimethoxymethyl)benzene수율 88.2%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Commercial 2-(3-Bromo-phenyl)-[1,3]dioxolane (1.3 mL, 8.64 mmol) was dissolved in anhydrous MeOH (40 mL) and catalytic amount of H2SO4 was added. The resulting reaction mixture was stirred 4 h at rt and finally extracted with petroleum ether (3×50 mL). The combined organic phases were washed with NaHCO3 (40 mL), dried (MgSO4), filtered and concentrated under vacuum to give 22b as a colourless oil (1.76 g, 88%), whose spectroscopic data were in close agreement with literature (29).

후처리

  1. customThe resulting reaction mixture
  2. extractionfinally extracted with petroleum ether (3×50 mL)
  3. washThe combined organic phases were washed with NaHCO3 (40 mL)
  4. dry with materialdried (MgSO4)
  5. filtrationfiltered
  6. concentrationconcentrated under vacuum

출처 및 근거

ORD 기록
ord-32e66d79d850497f94cd15625df312b4
출처 데이터셋
uspto-grants-2007_09
특허 번호
US07271186B1

반응 노트

불러오는 중…