Acetaldehyde → 1-{3-[4-Amino-7-(1-ethyl-piperidin-4-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl]-phenyl}-3-(3,5-dichloro-phenyl)-urea

참여 물질

역할	이름	HCID	투입량
반응물	Acetaldehyde	HCID 177	—
반응물	Sodium triacetoxyborohydride	HCID 5049666	—
반응물	1-[3-(4-Amino-7-piperidin-4-yl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-phenyl]-3-(3,5-dichloro-phenyl)-urea	HCID 67219862	—
용매	tetrahydrofuran N,N-dimethylformamide	HCID 21974620	—
생성물	1-{3-[4-Amino-7-(1-ethyl-piperidin-4-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl]-phenyl}-3-(3,5-dichloro-phenyl)-urea	HCID 67220433	10.5%

반응 단계

A solution of 1-[3-(4-Amino-7-piperidin-4-yl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-phenyl]-3-(3,5-dichloro-phenyl)-urea (100 mg, 0.19 mmol) and acetaldehyde (8.4 mg, 0.19 mmol) in DMF/THF (20%, 10 mL) was stirred for 30 minutes at room temperature. Sodium triacetoxyborohydride (61 mg, 0.29 mmol) was added to the reaction mixture, stirred for 3.5 hours, and concentrated in vacuo. Purification by reverse phase preparative HPLC (HPLC method 2) provided the title compound as a white solid (11 mg, 10%). MS: 553.5 (MH+); HPLC Rf: 1.7 min. (HPLC method 2); HPLC purity: 100%.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07271262B2
출처 데이터셋	uspto-grants-2007_09
ORD ID	ord-954eba2bdeda4fa7bcacefd67edd5c6b
출처 메모	uspto-grants-2007_09