참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethyl isocyanate | HCID 8022 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 2-Aminobenzothiazole-6-carbonitrile | HCID 4327139 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | N-(6-Cyano-1,3-benzothiazol-2-yl)-N'-ethylurea | HCID 21985533 | — |
반응 단계
0.2 grams of 2-amino-1,3-benzothiazole-6-carbonitrile is dissolved in about 5 ml dimethylformamide. About 0.2 ml of ethylisocyanate is added followed by about 0.3 ml triethylamine and the solution is heated to about 80° C. under good agitation. The solution is allowed to stir for about 4 hours then cooled to RT. The solvent is removed in vacuo and the solids are washed well with ether. The product is further purified by column chromatography and after drying in vacuo, about 0.14 grams is isolated.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07091227B2 |
|---|
| 출처 데이터셋 | uspto-grants-2006_08 |
|---|
| ORD ID | ord-b5781a6f057c43938316f29e4db42aaf |
|---|
| 출처 메모 | uspto-grants-2006_08 |
|---|
