3-(4-Hydroxybut-1-ynyl)phenyl acetate → HCID 68981033, 화합물
반응식
[C:1]([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([C:11]#[C:12][CH2:13][CH2:14][OH:15])[CH:6]=1)(=[O:3])[CH3:2]>C(OCC)(=O)C.C(O)C.[Pd]>[C:1]([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH2:11][CH2:12][CH2:13][CH2:14][OH:15])[CH:6]=1)(=[O:3])[CH3:2]참가 물질
5
실험 절차
A solution of 3-(4-hydroxybut-1-ynyl)phenyl acetate (4.47 g) was hydrogenated over 5% Pd on carbon in ethyl acetate (100 mL) and ethanol (100 mL) over 20 h. The reaction mixture was filtered through celite under nitrogen, and the filtrate was concentrated in vacua. The residue was purified by chromatography (SPE, gradient from cyclohexane to EtOAc) to give the title compound. LCMS RT=2.64 min
후처리
- filtrationThe reaction mixture was filtered through celite under nitrogen
- concentrationthe filtrate was concentrated in vacua
- customThe residue was purified by chromatography (SPE, gradient from cyclohexane to EtOAc)
출처 및 근거
- ORD 기록
- ord-4371f1abf2874ab6b921aeff0b4848f1
- 출처 데이터셋
- uspto-grants-2007_09
- 특허 번호
- US07271197B2
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