Probucol → HCID 178460886, 화합물

HRID 916986

반응식

CC(C1C=C(S[C:17]([S:20][C:21]2[CH:26]=[C:25]([C:27]([CH3:30])([CH3:29])[CH3:28])[C:24]([OH:31])=[C:23]([C:32]([CH3:35])([CH3:34])[CH3:33])[CH:22]=2)([CH3:19])[CH3:18])C=C(C(C)(C)C)C=1O)(C)C.C(OC1[O:43][C@H:42]([CH2:44][OH:45])[C@@H:41]([CH2:46]O)[O:40]1)C>>[C:32]([C:23]1[CH:22]=[C:21]([SH:20]([CH:17]([CH3:18])[CH3:19])[S:20][C:21]2[CH:22]=[C:23]([C:32]([CH3:33])([CH3:34])[CH3:35])[C:24]([OH:31])=[C:25]([C:27]([CH3:30])([CH3:29])[CH3:28])[CH:26]=2)[CH:26]=[C:25]([C:27]([CH3:30])([CH3:28])[CH3:29])[C:24]=1[O:31][CH2:46][C@@H:41]([OH:40])[C@H:42]([OH:43])[CH2:44][OH:45])([CH3:33])([CH3:35])[CH3:34]

참가 물질

반응물 2

HCID 4912Probucol

HCID 585933702-ethoxy-1,3-dioxolane-4(R),5(R)-dimethanol

생성물 1

HCID 178460886HCID 178460886, 화합물

실험 절차

The title compound was prepared using the same procedure as described in Ex-1 starting from probucol and 2-ethoxy-1,3-dioxolane-4(R),5(R)-dimethanol. White solid, mp 69–71° C. 1H-NMR (CDCl3) δ 7.56 (s, 2H, Ph-H), 7.45 (s, 2H, Ph-H), 5.38 (s, 1H, PhOH), 4.2{tilde over (5)}4.32 (m, 1H, PhOCH2CH), 3.96 (dd, J=9, 10, 1H, CH—O—), 3.7{tilde over (2)}3.86 (m, 4H, , CH—O—), 3.0{tilde over (0)}3.40 (m, 3H, OH), 1.46 (s, 6H, S,S′-isopropylidene), 1.45 (s, 18H, tert-butyls), 1.43 (s, 18H, tert-butyls). MS m/z: 643 ([M+Na]+, 100%). Anal. calcd. for C35H56O5S2.⅓H2O: C67.05, H9.11, S, 10.23; found: C67.03, H9.06, S10.01.

출처 및 근거

ORD 기록: ord-3c287712a4f44eee9fe18b82e2b3ba1b
출처 데이터셋: uspto-grants-2007_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07271274B2

연결된 노트

불러오는 중…