참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethyl isocyanate | HCID 8022 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 2-Benzothiazolamine, 6-bromo- | HCID 85149 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 1-(6-Bromo-2-benzothiazolyl)-3-ethylurea | HCID 21985564 | — |
반응 단계
About 0.75 g of 6-bromo-1,3-benzothiazol-2-amine (crude) is dissolved in about 15 mL DMF. About 0.5 mL of ethylisocyanate is added followed by about 0.9 mL triethylamine and the solution is heated to about 80° C. under good agitation. The solution is allowed to stir for about 4 hours then cooled to RT. The solvent is removed in vacuo and the solids are washed well with ether. The product is further purified by column chromatography.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07091227B2 |
|---|
| 출처 데이터셋 | uspto-grants-2006_08 |
|---|
| ORD ID | ord-0c31608d9ad04d16b80f61e52ee18c38 |
|---|
| 출처 메모 | uspto-grants-2006_08 |
|---|
