참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Methyl iodide | HCID 6328 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 4-Acetylbutyric acid | HCID 18407 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Methyl 5-oxohexanoate | HCID 84129 | 90% |
반응 단계
To 80 ml of N,N-dimethylformamide, 25 g (0.19 mol) of 5-oxohexanoic acid and 43 g (0.31 mol) of potassium carbonate were dissolved and heated at 50° C., followed by drop-wisely adding 41 g (0.29 mol) of methyl iodide and stirring at the same temperature for 2 hours. To this mixture, 150 ml of water was added, followed by extracting with diethyl ether (200 ml×4). The organic layer was washed with a saturated saline solution, followed by drying over anhydrous magnesium sulfate and concentrating under reduced pressure to obtain 24.9 g (yield: 90%) of methyl 5-oxohexanoate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07273878B2 |
|---|
| 출처 데이터셋 | uspto-grants-2007_09 |
|---|
| ORD ID | ord-bad5e512292141079f15f63ff88e8288 |
|---|
| 출처 메모 | uspto-grants-2007_09 |
|---|
