Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → Ethyl 6-chloro-4-(2-fluoro-4-methylanilino)nicotinate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 2-Fluoro-4-methylaniline | HCID 67984 | — |
| 반응물 | Ethyl 4,6-dichloropyridine-3-carboxylate | HCID 600045 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | Ethyl 6-chloro-4-(2-fluoro-4-methylanilino)nicotinate | HCID 23630706 | 44% |
반응 단계
2-Fluoro-4-methylaniline and ethyl 4,6-dichloronicotinate were reacted in a mixture of EtOH and conc. HCl as for example 33, step A. The resultant solid was isolated by filtration and washed with 10% Et2O/Hexane, to give ethyl 6-chloro-4-(2-fluoro-4-methylanilino)nicotinate (44%); m.p. (EtOH/water) 107-109° C. 1H NMR [400 MHz, CDCl3] δ 9.63 (br s, 1H), 8.77 (s, 1H), 7.20 (t, J=8.2 Hz, 1H), 7.05-6.99 (m, 2H), 6.65 (d, J=1.6 Hz, 1H), 4.41 (q, J=7.1 Hz, 2H), 1.43 (t, J=7.1 Hz, 3H). MS (FAB+) 309 (40%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07273877B2 |
| 출처 데이터셋 | uspto-grants-2007_09 |
| ORD ID | ord-b6c4aa72cff54fcd8690395d0accb8fa |
| 출처 메모 | uspto-grants-2007_09 |