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Ethanolamine → 2-(4-Phenoxymethylphenoxy)-propionic acid

HRID 917901
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반응식

HRID 917901 반응식
[O:1]([CH2:8][C:9]1[CH:20]=[CH:19][C:12]([O:13][CH:14]([CH3:18])[C:15]([OH:17])=[O:16])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(Cl)(Cl)=O.[CH2:25]([CH2:27][NH2:28])[OH:26]>CN(P(N(C)C)(N(C)C)=O)C>[OH:26][CH2:25][CH2:27][NH-:28].[O:1]([CH2:8][C:9]1[CH:10]=[CH:11][C:12]([O:13][CH:14]([CH3:18])[C:15]([OH:17])=[O:16])=[CH:19][CH:20]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 700EthanolamineHCID 24386Thionyl ChlorideHCID 214211732-(4-Phenoxymethylphenoxy)-propionic acid

생성물 2

HCID 214211732-(4-Phenoxymethylphenoxy)-propionic acidHCID 867336622-Hydroxyethylamide

시약·촉매·용매 1

HCID 12679Hexamethylphosphoramide용매

실험 절차

2.72 g. of 2-(4-phenoxymethylphenoxy)-propionic acid is dissolved in 12 ml. of HMPA. At -10°, 0.77 ml. of thionyl chloride is added thereto, and the mixture is agitated for 2 hours at -5°. Thereafter, 2.5 ml. of ethanolamine is added and the reaction mixture is stirred overnight at 20°. The mixture is then poured on ice and worked up as usual, yielding the 2-hydroxyethylamide of 2-(4-phenoxymethylphenoxy)-propionic acid.

후처리

  1. customAt -10°
  2. stirringthe reaction mixture is stirred overnight at 20°
  3. additionThe mixture is then poured on ice

출처 및 근거

ORD 기록
ord-06cba50a81ab4a12858d628714511fe3
출처 데이터셋
uspto-grants-1976_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US03968143

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