Thionyl Chloride → 29030-58-8

HRID 917916노트

반응식

HRID 917916 반응식
[CH:1]1([C:7]2[CH:12]=[CH:11][C:10]([CH2:13][C:14]([NH2:16])=O)=[CH:9][CH:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.S(Cl)(Cl)=O>>[CH:1]1([C:7]2[CH:8]=[CH:9][C:10]([CH2:13][C:14]#[N:16])=[CH:11][CH:12]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 13030798HCID 13030798, 화합물

생성물 1

HCID 2024547429030-58-8

실험 절차

17.3 g of para-cyclohexyl-phenylacetamide and 35 ml of thionyl chloride are stirred at 70°C for 3 hours. The excess thionyl chloride is evaporated, the residue dissolved in ethyl acetate, and the solution washed with sodium bicarbonate solution and water. The solvent is evaporated and the residue distilled in a high vacuum. There is obtained paracyclohexylphenylacetonitrile boiling at 131°-132°C under a pressure of 0.35 mm of Hg and melting at 48°-49°C.

후처리

  1. customThe excess thionyl chloride is evaporated
  2. dissolutionthe residue dissolved in ethyl acetate
  3. washthe solution washed with sodium bicarbonate solution and water
  4. customThe solvent is evaporated
  5. distillationthe residue distilled in a high vacuum

출처 및 근거

ORD 기록
ord-ba90b6daa13f4762869b6b85a7d2c976
출처 데이터셋
uspto-grants-1976_07
특허 번호
US03968142

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