Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethanol → 10-methyl-2,3-dihydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H,11aH)-dione
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | N-Methylisatoic anhydride | HCID 25160 | — |
| 반응물 | L-Proline | HCID 145742 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 생성물 | 10-methyl-2,3-dihydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H,11aH)-dione | HCID 9859436 | — |
반응 단계
N-Methyl isatoic anhydride (I) and L-proline (II) are reacted in a solvent such as ethanol or dimethyl sulfoxide at 25° to 200°C. for a period of 1 to 24 hours to produce the dextrorotatory isomer of 1,2,3,11a-tetrahydro-10-methyl-5H-pyrrolo[2,1-c] [1,4]benzodiazepin-5,11(10H)-dione.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US03968230 |
| 출처 데이터셋 | uspto-grants-1976_07 |
| ORD ID | ord-06d73c775e6b4ce89d097791aa6fe1b2 |
| 출처 메모 | uspto-grants-1976_07 |