(-)-1-(N-methylanthraniloyl)-proline → 10-methyl-2,3-dihydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H,11aH)-dione
반응식
[CH3:1][NH:2][C:3]1[C:4](=[CH:15][CH:16]=[CH:17][CH:18]=1)[C:5]([N:7]1[CH2:14][CH2:13][CH2:12][C@H:8]1[C:9](O)=[O:10])=[O:6]>O1CCCC1>[CH3:1][N:2]1[C:3]2[CH:18]=[CH:17][CH:16]=[CH:15][C:4]=2[C:5](=[O:6])[N:7]2[CH2:14][CH2:13][CH2:12][CH:8]2[C:9]1=[O:10]참가 물질
3
실험 절차
A mixture of 24.8 g. of (-)-1-(N-methylanthraniloyl)proline and 18.0 g. of N,N'-carbonyldiimidazole in 300 ml. of dry tetrahydrofuran is stirred for 2 hours at room temperature and then heated at reflux temperature for 3 hours. The reaction mixture is concentrated to remove the solvent and the residue is extracted into benzene. The benzene solution is washed twice with water and concentrated to recover the desired product.
후처리
- additionA mixture of 24.8 g
- temperatureheated
- temperatureat reflux temperature for 3 hours
- concentrationThe reaction mixture is concentrated
- customto remove the solvent
- extractionthe residue is extracted into benzene
- washThe benzene solution is washed twice with water
- concentrationconcentrated
- customto recover the desired product
출처 및 근거
- ORD 기록
- ord-a9760acb26c648a18ae773d7462e2c88
- 출처 데이터셋
- uspto-grants-1976_07
- 특허 번호
- US03968230
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