Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 4'-(3-(1-Pyrrolidinyl)propionyl)methanesulfonanilide hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Formaldehyde | HCID 712 | — |
| 반응물 | Pyrrolidine, hydrochloride (1:1) | HCID 212848 | — |
| 반응물 | N-(4-acetylphenyl)methanesulfonamide | HCID 684083 | — |
| 촉매 | Ethanol | HCID 702 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 4'-(3-(1-Pyrrolidinyl)propionyl)methanesulfonanilide hydrochloride | HCID 3042693 | — |
반응 단계
A mixture of 4'-acetylmethanesulfonanilide (21.5 g., 0.1 mole), 95% paraformaldehyde (10 g., 0.3 mole), pyrrolidine hydrochloride (10.8 g., 0.1 mole) in 150 ml. of ethanol containing 1 drop of concentrated hydrochloric acid is refluxed for a period of 4 hr. at steam bath temperature and then for an additional period of 8 hr. permitting the ethanol to evaporate. The resulting glassy residue is stirred with 300 ml. of hot acetone providing a crystalline material which is collected and crystallized from methanol-isopropyl alcohol to afford analytically pure 4'-[3-(1-PYRROLIDINYL)PROPIONYL]-METHANESULFONANILIDE HYDROCHLORIDE, m.p. 182.0°-183.0°C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US03968242 |
| 출처 데이터셋 | uspto-grants-1976_07 |
| ORD ID | ord-e567233c2e9e45eba084244edecee822 |
| 출처 메모 | uspto-grants-1976_07 |