Toluene → 3-(2-Fluoro-4-biphenylyl)-1-butyl pelargonate

HRID 918152노트

반응식

HRID 918152 반응식
[F:1][C:2]1[CH:7]=[C:6]([CH:8]([CH3:12])[CH2:9][CH2:10][OH:11])[CH:5]=[CH:4][C:3]=1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.[C:19](O)(=[O:28])[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27].C1(C)C=CC(S(O)(=O)=O)=CC=1.C1(C)C=CC=CC=1>O>[C:19]([O:11][CH2:10][CH2:9][CH:8]([C:6]1[CH:5]=[CH:4][C:3]([C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)=[C:2]([F:1])[CH:7]=1)[CH3:12])(=[O:28])[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27]

참가 물질

6

반응물 4

HCID 1140TolueneHCID 6101p-Toluenesulfonic acidHCID 8158Nonanoic AcidHCID 215232653-(2-Fluoro-4-biphenylyl)-1-butanol

생성물 1

HCID 537574883-(2-Fluoro-4-biphenylyl)-1-butyl pelargonate

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture consisting of 6.11 gm (0.025 mol) of 3-(2-fluoro-4-biphenylyl)-1-butanol, 4.27 gm (0.027 mol) of pelargonic acid, 0.25 gm of p-toluene-sulfonic acid and 50 ml of absolute toluene was refluxed in a vessel equipped with a water trap until no more water separated out. Thereafter, the reaction solution was diluted with ether, the organic solution was extracted with water, dilute ammonia and again with water, dried over sodium sulfate, and the solvent was distilled off. 6.45 gm (67% of theory) of the ester of the formula ##EQU26## having a boiling point of 183°-190°C at 0.1 mm Hg were obtained.

후처리

  1. temperaturewas refluxed in a vessel
  2. customseparated out
  3. additionThereafter, the reaction solution was diluted with ether
  4. extractionthe organic solution was extracted with water, dilute ammonia and again with water
  5. dry with materialdried over sodium sulfate
  6. distillationthe solvent was distilled off
  7. customwere obtained

출처 및 근거

ORD 기록
ord-b61bee4f63294196986aaa45ab18613a
출처 데이터셋
uspto-grants-1976_07
특허 번호
US03969419

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