Chloroacetyl chloride → HCID 178514674, 화합물

HRID 918187노트

반응식

HRID 918187 반응식
[S:1]([C:5]1[CH:11]=[C:10]([S:12](=[O:15])(=[O:14])[NH2:13])[C:9]([Br:16])=[CH:8][C:6]=1[NH2:7])(=[O:4])(=[O:3])[NH2:2].[Cl:17][CH2:18][C:19](Cl)=O>O1CCOCC1>[Cl:17][CH2:18][C:19]1[NH:2][S:1](=[O:3])(=[O:4])[C:5]2[CH:11]=[C:10]([S:12](=[O:14])(=[O:15])[NH2:13])[C:9]([Br:16])=[CH:8][C:6]=2[N:7]=1

참가 물질

4

반응물 2

HCID 6577Chloroacetyl chlorideHCID 5177804-Amino-6-bromo-1,3-benzenedisulfonamide

생성물 1

HCID 178514674HCID 178514674, 화합물

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

A mixture of 2,4-disulfamoyl-5-bromoaniline (0.02 mole) and chloroacetyl chloride (0.022 mole) in 75 ml. of dioxane is heated under reflux for about 24 hours and then concentrated to dryness. The residue is dissolved in ethanol and then heated on the steam bath in a mixture of 2.0 g. of potassium or sodium acetate and 50 ml. of water for two hours. The solution is cooled and the product separated by acidification with hydrochloric acid and purified by recrystallization from a mixture of ethanol and water.

후처리

  1. temperatureunder reflux for about 24 hours
  2. concentrationconcentrated to dryness
  3. dissolutionThe residue is dissolved in ethanol
  4. temperatureheated on the steam bath in a mixture of 2.0 g
  5. temperatureThe solution is cooled
  6. customthe product separated by acidification with hydrochloric acid
  7. custompurified by recrystallization from a mixture of ethanol and water

출처 및 근거

ORD 기록
ord-29a48bc9dea84cd8804df219eb6e4a9b
출처 데이터셋
uspto-grants-1976_07
특허 번호
US03969518

반응 노트

불러오는 중…