Sulfuric Acid → 4,8-Dimethyl-7-nonen-2-one

HRID 918323

반응식

HRID 918323 반응식
[CH3:1][CH:2]([CH2:7][CH2:8][CH:9]=[C:10]([CH3:12])[CH3:11])[CH2:3][CH:4]([OH:6])[CH3:5].C(Cl)Cl.[Cr](O[Cr]([O-])(=O)=O)([O-])(=O)=O.[Na+].[Na+].S(=O)(=O)(O)O>O>[CH3:1][CH:2]([CH2:7][CH2:8][CH:9]=[C:10]([CH3:11])[CH3:12])[CH2:3][C:4](=[O:6])[CH3:5]

참가 물질

6

반응물 4

HCID 1118Sulfuric AcidHCID 6344DichloromethaneHCID 25408Sodium DichromateHCID 1624184,8-Dimethyl-7-nonen-2-ol

생성물 1

HCID 193164,8-Dimethyl-7-nonen-2-one

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

A solution of 47 g. of 4,8-dimethylnon-7-en-2-ol in 250 ml. of methylene chloride is cooled to about 10° as a solution of 46.4 g. of sodium dichromate in 125 ml. of water is added. The mixture is at about 10° as a solution of 46.3 g. of sulfuric acid in 100 ml. of water is added over about 45 minutes. The mixture is allowed to attain room temperature and, after about 3 hours, the organic layer is separated and the aqueous layer is extracted with methylene chloride. The combined organic materials are washed with saturated potassium bicarbonate, water and saturated sodium chloride, dried over magnesium sulfate and evaporated to yield 4,8-dimethylnon-7-en-2-one.

후처리

  1. customis at about 10° as a solution of 46.3 g
  2. customthe organic layer is separated
  3. extractionthe aqueous layer is extracted with methylene chloride
  4. washThe combined organic materials are washed with saturated potassium bicarbonate, water and saturated sodium chloride
  5. dry with materialdried over magnesium sulfate
  6. customevaporated

출처 및 근거

ORD 기록
ord-628eaf71d14c40d8b3e85f2b908bcceb
출처 데이터셋
uspto-grants-1976_07
특허 번호
US03970704

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