Maleimide → 3-(5-methyl-1H-indol-3-yl)pyrrolidine-2,5-dione
반응식
[CH3:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[CH:5]2.[C:11]1(=[O:17])[NH:15][C:14](=[O:16])[CH:13]=[CH:12]1>C(O)(=O)C>[CH3:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:13]1[CH2:12][C:11](=[O:17])[NH:15][C:14]1=[O:16]참가 물질
4
실험 절차
5-Methyl indole (10 g, 76 mmol) and maleimide (7.4 g, 76 mmol) in 77 mL of glacial acetic acid was heated at 90° C. for 24 h. The reaction mixture was cooled to RT, and the acetic acid was evaporated under reduced pressure. The residue was suspended in diethyl ether and filtered to obtain solid product (7 g).
후처리
- customthe acetic acid was evaporated under reduced pressure
- filtrationfiltered
출처 및 근거
- ORD 기록
- ord-e263406efc4e4511a115f4c8388cbe6a
- 출처 데이터셋
- uspto-grants-2016_03
- 특허 번호
- US09271971B2
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