Maleimide → 3-(5-methyl-1H-indol-3-yl)pyrrolidine-2,5-dione

HRID 918896

반응식

HRID 918896 반응식
[CH3:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[CH:5]2.[C:11]1(=[O:17])[NH:15][C:14](=[O:16])[CH:13]=[CH:12]1>C(O)(=O)C>[CH3:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:13]1[CH2:12][C:11](=[O:17])[NH:15][C:14]1=[O:16]

참가 물질

4

반응물 2

HCID 10935MaleimideHCID 119785-Methylindole

생성물 1

HCID 670364713-(5-methyl-1H-indol-3-yl)pyrrolidine-2,5-dione수율 40.4%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

5-Methyl indole (10 g, 76 mmol) and maleimide (7.4 g, 76 mmol) in 77 mL of glacial acetic acid was heated at 90° C. for 24 h. The reaction mixture was cooled to RT, and the acetic acid was evaporated under reduced pressure. The residue was suspended in diethyl ether and filtered to obtain solid product (7 g).

후처리

  1. customthe acetic acid was evaporated under reduced pressure
  2. filtrationfiltered

출처 및 근거

ORD 기록
ord-e263406efc4e4511a115f4c8388cbe6a
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09271971B2

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