1-Bromo-4-iodobenzene → [1-(4'-Bromo-biphenyl-4-yl)-cyclopropyl]-acetic acid ethyl ester

반응식

[CH2:1]([O:3][C:4](=[O:24])[CH2:5][C:6]1([C:9]2[CH:14]=[CH:13][C:12](B3OC(C)(C)C(C)(C)O3)=[CH:11][CH:10]=2)[CH2:8][CH2:7]1)[CH3:2].[Br:25][C:26]1[CH:31]=[CH:30][C:29](I)=[CH:28][CH:27]=1>>[CH2:1]([O:3][C:4](=[O:24])[CH2:5][C:6]1([C:9]2[CH:10]=[CH:11][C:12]([C:29]3[CH:30]=[CH:31][C:26]([Br:25])=[CH:27][CH:28]=3)=[CH:13][CH:14]=2)[CH2:7][CH2:8]1)[CH3:2]

참가 물질

반응물 2

HCID 115221-Bromo-4-iodobenzene

HCID 66578040{1-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]cyclopropyl}-acetic acid ethyl ester

생성물 1

HCID 67958087[1-(4'-Bromo-biphenyl-4-yl)-cyclopropyl]-acetic acid ethyl ester

실험 절차

Prepared according to the procedure described in Example 5, Step 2, using the following starting materials: {1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-cyclopropyl}-acetic acid ethyl ester and 1-bromo-4-iodo-benzene.

후처리

customPrepared

출처 및 근거

ORD 기록: ord-b7d89cbefa354ae09a933dee96c31b6e
출처 데이터셋: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09272990B2

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