1-(4-Bromo-pyridin-3-yl)-4-phenyl-butan-1-ol → 1-{4'-[3-(1-Hydroxy-4-phenyl-butyl)-pyridin-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl ester

HRID 919067

반응식

HRID 919067 반응식
[CH2:1]([O:3][C:4]([C:6]1([C:9]2[CH:14]=[CH:13][C:12]([C:15]3[CH:20]=[CH:19][C:18](B4OC(C)(C)C(C)(C)O4)=[CH:17][CH:16]=3)=[CH:11][CH:10]=2)[CH2:8][CH2:7]1)=[O:5])[CH3:2].Br[C:31]1[CH:36]=[CH:35][N:34]=[CH:33][C:32]=1[CH:37]([OH:47])[CH2:38][CH2:39][CH2:40][C:41]1[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=1>>[CH2:1]([O:3][C:4]([C:6]1([C:9]2[CH:10]=[CH:11][C:12]([C:15]3[CH:16]=[CH:17][C:18]([C:31]4[CH:36]=[CH:35][N:34]=[CH:33][C:32]=4[CH:37]([OH:47])[CH2:38][CH2:39][CH2:40][C:41]4[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=4)=[CH:19][CH:20]=3)=[CH:13][CH:14]=2)[CH2:8][CH2:7]1)=[O:5])[CH3:2]

참가 물질

3

반응물 2

HCID 679577791-(4-Bromo-pyridin-3-yl)-4-phenyl-butan-1-olHCID 679580391-[4'-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester

생성물 1

HCID 679577961-{4'-[3-(1-Hydroxy-4-phenyl-butyl)-pyridin-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl ester

실험 절차

Prepared according to the procedure described in Example 1, Step 2, using the following starting materials: 1-[4′-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester and 1-(4-bromo-pyridin-3-yl)-4-phenyl-butan-1-ol.

후처리

  1. customPrepared

출처 및 근거

ORD 기록
ord-f53c921d69274aa7b649ddf0f4246fa0
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09272990B2

연결된 노트

불러오는 중…