3-Chloroisoquinoline-4-carbaldehyde → 1-(3-Chloro-isoquinolin-4-yl)-4-phenyl-butan-1-ol

HRID 919076노트

반응식

HRID 919076 반응식
[Cl:1][C:2]1[N:3]=[CH:4][C:5]2[C:10]([C:11]=1[CH:12]=[O:13])=[CH:9][CH:8]=[CH:7][CH:6]=2.[C:14]1([CH2:20][CH2:21][CH2:22][Mg]Br)[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[Cl:1][C:2]1[N:3]=[CH:4][C:5]2[C:10]([C:11]=1[CH:12]([OH:13])[CH2:22][CH2:21][CH2:20][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2

참가 물질

3

반응물 2

HCID 145672793-Chloroisoquinoline-4-carbaldehydeHCID 178418471HCID 178418471, 화합물

생성물 1

HCID 866970891-(3-Chloro-isoquinolin-4-yl)-4-phenyl-butan-1-ol

실험 절차

Prepared according to the procedure described in Example 5, Step 1, using the following starting materials: 3-chloro-isoquinoline-4-carbaldehyde and 3-phenyl-propyl magnesium bromide.

후처리

  1. customPrepared

출처 및 근거

ORD 기록
ord-97dbd75c09e54d82aa6859fb0bbf4602
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09272990B2

반응 노트

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