methyl (2E)-3-[6-(hydroxymethyl)pyridin-3-yl]acrylate → Methyl 3-[6-(Hydroxymethyl)pyridin-3-yl]propanoic acid

반응식

[OH:1][CH2:2][C:3]1[N:8]=[CH:7][C:6](/[CH:9]=[CH:10]/[C:11]([O:13]C)=[O:12])=[CH:5][CH:4]=1.[CH3:15]C(CC1C=CC(CO)=CC=1)C(O)=O>>[CH3:15][CH:10]([CH2:9][C:6]1[CH:7]=[N:8][C:3]([CH2:2][OH:1])=[CH:4][CH:5]=1)[C:11]([OH:13])=[O:12]

참가 물질

반응물 2

HCID 59145577methyl (2E)-3-[6-(hydroxymethyl)pyridin-3-yl]acrylate

HCID 67022307Methyl 3-[4-(hydroxymethyl)phenyl]propanoic acid

생성물 1

HCID 67022329Methyl 3-[6-(Hydroxymethyl)pyridin-3-yl]propanoic acid

실험 절차

The title compound was prepared from Intermediate G acid by the same methodology used to make Intermediate B.

출처 및 근거

ORD 기록: ord-41e0c1d6813a42a3a831a15a4b6224dd
출처 데이터셋: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09273003B2

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