Methyl propiolate → HCID 86714138, 화합물

HRID 919868

반응식

HRID 919868 반응식
[CH2:1]([O:3][C:4](=[O:15])[CH:5]=[C:6]([NH:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH3:7])[CH3:2].[CH3:16][O:17][C:18](=[O:21])[C:19]#[CH:20]>CO>[CH3:16][O:17][C:18](=[O:21])[CH:19]=[CH:20][C:5](=[C:6]([NH:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH3:7])[C:4]([O:3][CH2:1][CH3:2])=[O:15]

참가 물질

4

반응물 2

HCID 13536Methyl propiolateHCID 94928Ethyl 3-anilinobut-2-enoate

생성물 1

HCID 86714138HCID 86714138, 화합물수율 59.6%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 3-phenylamino-but-2-enoic acid ethyl ester (7 g, 34.1 mmol) and propynoic acid methyl ester (4.6 mL, 51.2 mmol) in MeOH (114 mL) was refluxed for 48 h. The solvent was evaporated, and the crude oil was purified by silica gel chromatography (0-20% EtOAc/hexanes) to give 5.88 g of the title compound as an orange oil. MS: (+) m/z 290.27 (M+1).

후처리

  1. temperaturewas refluxed for 48 h
  2. customThe solvent was evaporated
  3. customthe crude oil was purified by silica gel chromatography (0-20% EtOAc/hexanes)

출처 및 근거

ORD 기록
ord-ab242cb9833242d9af20b9f7b5f7cb71
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09271970B2

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